Original paper
CD7 CAR T Cells for the Therapy of Acute Myeloid Leukemia
Abstract
Chimeric antigen receptor (CAR) T cell therapy for the treatment of acute myeloid leukemia (AML) has the risk of toxicity to normal myeloid cells. CD7 is expressed by the leukemic blasts and malignant progenitor cells of approximately 30% of AML patients but is absent on normal myeloid and erythroid cells. Since CD7 expression by malignant blasts is also linked with chemoresistance and poor outcomes, targeting this antigen may be beneficial for...
Paper Details
Title
CD7 CAR T Cells for the Therapy of Acute Myeloid Leukemia
Published Date
Jan 1, 2019
Journal
Volume
27
Issue
1
Pages
272 - 280
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Notes
History