Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
Abstract
Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major...
Paper Details
Title
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
Published Date
Oct 8, 2018
Journal
Volume
1
Issue
1
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