Comparative analysis of circulating tumour cells detection and circulating tumor DNA in liquid biopsy for the diagnosis of early stage pancreatic adenocarcinoma

Aim: Pancreatic ductal adenocarcinoma (PDAC) survival rarely exceed 20% except if the tumor is small (< 20mm or pT1). A way to improve survival is to perform early diagnosis and find simple diagnosis tool. Searching for tumour elements in body fluids might provide diagnosis assistance. The aim of this study was to test liquid biopsy method in patient with early stage PDAC. Methods: First, we tested 2 CTC enrichment methods (density gradient...