Conformationally Unambiguous Spin Label for Exploring the Binding Site Topology of Multivalent Systems

Multivalent carbohydrate–lectin interactions are a key concept in biological processes mediating, for example, signaling and adhesion. Binding affinities of multivalent ligands often increase by orders of magnitude compared to a monovalent binding situation. Thus, the design of multivalent ligands as potent inhibitors is a highly active field of research, where knowledge about the binding site topology is crucial. Here, we report a general...