Match!

Mesenteric Adipose Tissue Alterations in Crohn’s Disease Are Associated With the Lymphatic System

Published on Jan 10, 2019in Inflammatory Bowel Diseases4.005
· DOI :10.1093/ibd/izy306
Weisong Shen2
Estimated H-index: 2
(NU: Nanjing University),
Yi Li17
Estimated H-index: 17
(NU: Nanjing University)
+ 5 AuthorsWeiming Zhu24
Estimated H-index: 24
(NU: Nanjing University)
Abstract
  • References (49)
  • Citations (3)
📖 Papers frequently viewed together
3 Citations
30 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References49
Newest
#1Calvin J. Coffey (UL: University of Limerick)H-Index: 4
#2Miranda G. Kiernan (UL: University of Limerick)H-Index: 6
Last. Colum P. Dunne (UL: University of Limerick)H-Index: 29
view all 23 authors...
27 CitationsSource
#1Sonia Rehal (U of C: University of Calgary)H-Index: 6
#2Pierre-Yves von der Weid (U of C: University of Calgary)H-Index: 23
Chronic inflammatory diseases are associated with a persistent and enhanced response to environmental antigens. As an adaptive response to this exaggerated immune state, affected tissue typically develops tertiary lymphoid organs. Studies of Crohn disease (CD), a chronic inflammatory disease of the intestinal tract, report tertiary lymphoid organs present within the mucosal wall, along with other lymphatic diseases, such as lymphangiogenesis and obstructed lymphatic vessels. These observations s...
10 CitationsSource
#1Yi Li (NU: Nanjing University)H-Index: 1
#2Weiming Zhu (NU: Nanjing University)H-Index: 24
Last. Bo Shen (Cleveland Clinic)H-Index: 56
view all 4 authors...
20 CitationsSource
#1Lugen Zuo (NU: Nanjing University)H-Index: 14
#2Yi Li (NU: Nanjing University)H-Index: 17
Last. Jieshou Li (NU: Nanjing University)H-Index: 40
view all 11 authors...
Abnormalities in mesenteric adipose tissue (MAT) have long been recognized; however, the functional changes in the mesenteric adipocytes as well as the underlying mechanisms are not entirely clear. The aim of this study was to analyze the function and morphology of the MAT in patients with Crohn's disease (CD) and the underlying mechanism.The MAT specimens were obtained from areas adjacent to the intestinal wall in patients with CD (n = 33) and without CD (control, n = 23) who underwent intestin...
12 CitationsSource
#1Y. Li (NU: Nanjing University)H-Index: 14
#2Wusheng Zhu (NU: Nanjing University)H-Index: 20
Last. Jie Li (NU: Nanjing University)H-Index: 48
view all 10 authors...
Aim Mesenteric hypertrophy has been recognized as an indicator of the complicated course of Crohn's disease. The aim of this study was to investigate whether the visceral fat area (VFA) is associated with postoperative clinical and endoscopic recurrence. Method Computed tomography was used to measure the subcutaneous fat area and VFA, and the mesenteric fat index (MFI) was defined as the ratio of the VFA to the subcutaneous fat area. Associations between body mass index, subcutaneous fat area, V...
33 CitationsSource
#1Pedro Gonçalves (French Institute of Health and Medical Research)H-Index: 3
#2Fernando Magro (Paris V: Paris Descartes University)H-Index: 32
Last. Fátima Martel (University of Porto)H-Index: 28
view all 3 authors...
Epidemiological studies show that both the incidence of inflammatory bowel disease (IBD) and the proportion of people with obesity and/or obesity-associated metabolic syndrome markedly increased in developed countries during the past half century. Obesity is also associated with the development of more active IBD and requirement for hospitalization and with a decrease in the time span between diagnosis and surgery. Patients with IBD, especially Crohn’s disease, present fat-wrapping or “creeping-...
21 CitationsSource
#1Lugen Zuo (NU: Nanjing University)H-Index: 14
#2Yi Li (NU: Nanjing University)H-Index: 17
Last. Jieshou Li (NU: Nanjing University)H-Index: 40
view all 11 authors...
Abstract Aims To observe the effect of cigarette smoke (CS) on the small bowel and colon in mice and to attempt to explain the potential mechanisms that account for these effects. Methods Male BALB/c mice age 6–8 weeks were randomly divided into a CS group and a control group (n = 10 per group). CS mice were exposed to CS (five cigarettes each time, four times a day for 5 days a week using Hamburg II smoking machine and CS was diluted with air at a ratio of 1:6) for 10 weeks, and control mice we...
24 CitationsSource
#1Yun Feng (NU: Nanjing University)H-Index: 2
#2Yi Li (NU: Nanjing University)H-Index: 17
Last. Jieshou Li (NU: Nanjing University)H-Index: 40
view all 10 authors...
Summary Background & aims Mesenteric adipose tissue hypertrophy is a hallmark of Crohn's disease and can express various adipokines. Exclusive enteral nutrition could effectively induce remission in Crohn's disease with mechanisms largely unknown. We investigated whether exclusive enteral nutrition could modify mesenteric fat in patients with active Crohn's disease. Methods Sixteen patients who underwent resection for ileum Crohn's disease were studied. As a control group, eight patients without...
23 CitationsSource
#1Yi Li (NU: Nanjing University)H-Index: 17
#2Weiming Zhu (NU: Nanjing University)H-Index: 24
Last. Jieshou Li (NU: Nanjing University)H-Index: 40
view all 10 authors...
18 CitationsSource
#1Ranjeet M. Dongaonkar (A&M: Texas A&M University)H-Index: 7
#2Tam L. Nguyen (A&M: Texas A&M University)H-Index: 2
Last. Randolph H. Stewart (A&M: Texas A&M University)H-Index: 19
view all 7 authors...
In vitro studies have revealed that acute increases in transmural pressure increase lymphatic vessel contractile function. However, adaptive responses to prolonged changes in transmural pressure in vivo have not been reported. Therefore, we developed a novel bovine mesenteric lymphatic partial constriction model to test the hypothesis that lymphatic vessels exposed to higher transmural pressures adapt functionally to become stronger pumps than vessels exposed to lower transmural pressures. Postn...
18 CitationsSource
Cited By3
Newest
#1Yi Li (NU: Nanjing University)H-Index: 19
#2Helen Mohan (University Hospital Limerick)H-Index: 1
Last. Weiming Zhu (NU: Nanjing University)H-Index: 24
view all 10 authors...
BACKGROUND: The structures of the mesentery including adipose tissue, nerves, and lymphatics play an important role in the pathogenesis and disease progression of Crohn's disease (CD). Conventional surgical resection for CD usually does not involve resecting the mesentery en bloc with the specimen. This contrasts with complete mesocolic excision (CME) in colorectal cancer, which involves radical resection of the mesentery. Preliminary evidence from smaller studies suggests that applying the prin...
1 CitationsSource
#1Francesca Aparecida Ramos da Silva (State University of Campinas)H-Index: 4
Last. Lício A. VellosoH-Index: 60
view all 13 authors...
BACKGROUND: Crohn's disease (CD) is a multifactorial disease characterized by chronic intestinal inflammation. The increased visceral adiposity near the affected intestinal area, of which mesenteric adipose tissue (MAT) is the main component, is a feature of CD. Both protective and pathological roles have been attributed to this disease-associated tissue in CD. To understand the contribution of MAT to CD pathophysiology, a molecular and cellular signature of disease-associated MAT in CD patients...
Source
#1Amandeep Singh (Cleveland Clinic)H-Index: 4
#2Brian Koenen (Cleveland Clinic)
Last. Donald F. Kirby (Cleveland Clinic)H-Index: 8
view all 3 authors...
Source
#1Matthew Stephens (U of C: University of Calgary)H-Index: 2
#2Shan Liao (U of C: University of Calgary)H-Index: 2
Last. Pierre-Yves von der Weid (U of C: University of Calgary)H-Index: 23
view all 3 authors...
Background – Inflammatory bowel disease (IBD) is characterised by both acute and chronic phase inflammation of the gastro-intestinal (GI) tract that affect a large and growing number of people worldwide with little to no effective treatments. This is in part due to the lack of understanding of the disease pathogenesis and also the currently poorly described involvement of other systems such as the lymphatics. During DSS induced colitis, mice also develop a severe inflammation of terminal ileum w...
1 CitationsSource
#1Xing-Xian GuoH-Index: 1
#2Xiao-Peng LiH-Index: 3
Last. Jing LiH-Index: 10
view all 13 authors...
Hepatocellular cancer (HCC) is a lethal malignancy with poor prognosis and easy recurrence. There are few agents with minor toxic side effects that can be used for treatment of HCC. Evodiamine (Evo), one of the major bioactive components derived from fructus Evodiae, has long been shown to exert anti-hepatocellular carcinoma activity by suppressing activation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK). In addition, in the Nucleotide-Binding Oligomerization Domain 1 ...
3 CitationsSource