DNA methylation profiling is a method of choice for molecular verification of pediatric WNT-activated medulloblastomas
Abstract
Wingless-activated medulloblastoma (WNT MB) represents a well-characterized molecular variant accounting for 10–15% of all MB and is associated with a favorable clinical outcome. Patients with localized WNT MBs could benefit from de-intensification of combined treatment, which would require an accurate diagnosis of these tumors. However, despite the presence of molecular features related with a WNT MB signature (nuclear ß-catenin...
Paper Details
Title
DNA methylation profiling is a method of choice for molecular verification of pediatric WNT-activated medulloblastomas
Published Date
Sep 25, 2018
Journal
Volume
21
Issue
2
Pages
214 - 221
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