Targeted Delivery of Cyclotides via Conjugation to a Nanobody
Abstract
Many naturally occurring peptides have poor proteolytic stability, which limits their therapeutic applications. Cyclotides are plant-derived cyclic peptides that resist proteolysis due to their highly constrained structure, comprising a head-to-tail cyclic backbone and three disulfide bonds that form a cystine-knotted core. This structure makes them useful as scaffolds onto which peptide sequences (epitopes) can be grafted. In this study, VHH7,...
Paper Details
Title
Targeted Delivery of Cyclotides via Conjugation to a Nanobody
Published Date
Sep 24, 2018
Journal
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