Original paper
Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell
Abstract
We report a patient relapsing 9 months after CD19-targeted CAR T cell (CTL019) infusion with CD19- leukemia that aberrantly expressed the anti-CD19 CAR. The CAR gene was unintentionally introduced into a single leukemic B cell during T cell manufacturing, and its product bound in cis to the CD19 epitope on the surface of leukemic cells, masking it from recognition by and conferring resistance to...
Paper Details
Title
Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell
Published Date
Oct 1, 2018
Journal
Volume
24
Issue
10
Pages
1499 - 1503
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History