The Senescence–Stemness Alliance – A Cancer-Hijacked Regeneration Principle

Cellular senescence with its cell-autonomous and cell non-autonomous implications is now recognized as a key component of development, tissue regeneration, aging-related pathologies, and cancer. The increasingly investigated biological consequences of the senescence-associated secretome are complex, spanning paracrine senescence, immune activation, and chronic inflammation. Senescence has been viewed as a static, molecularly fixed condition, and...