Original paper
PD-L1 blockade enhances anti-tumor efficacy of NK cells
Abstract
Anti-PD-1/anti-PD-L1 therapies have shown success in cancer treatment but responses are limited to ~ 15% of patients with lymphocyte infiltrated, PD-L1 positive tumors. Hence, strategies that increase PD-L1 expression and tumor infiltration should make more patients eligible for PD-1/PD-L1 blockade therapy, thus improving overall outcomes. PD-L1 expression on tumors is induced by IFNγ, a cytokine secreted by NK cells. Therefore, we tested if...
Paper Details
Title
PD-L1 blockade enhances anti-tumor efficacy of NK cells
Published Date
Aug 27, 2018
Journal
Volume
7
Issue
11
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Notes
History