Evaluation of selected traditional Chinese medical extracts for bone mineral density maintenance: A mechanistic study

To investigate the development of a minimal traditional Chinese medicine (TCM) formula using selected TCM ingredients and evaluating their biological activity with bone-specific in vitro tests. Finally, determining if the minimal formula can maintain bone mineral density (BMD) in a low bone mass (LBM)/osteoporosis (OP) model system. Sixteen different TCM plant extracts were tested for estrogenic, osteogenic and osteoclastic activities. Despite...