14-helical β-peptides Elicit Toxicity against C. albicans by Forming Pores in the Cell Membrane and Subsequently Disrupting Intracellular Organelles
Abstract
Synthetic peptidomimetics of antimicrobial peptides are promising as antimicrobial drug candidates because they promote membrane disruption and exhibit greater structural and proteolytic stability. We previously reported selective antifungal 14-helical beta-peptides, but the mechanism of antifungal toxicity of beta-peptides remains unknown. To provide insight into the mechanism, we studied antifungal beta-peptide binding to artificial membranes...
Paper Details
Title
14-helical β-peptides Elicit Toxicity against C. albicans by Forming Pores in the Cell Membrane and Subsequently Disrupting Intracellular Organelles
Published Date
Sep 29, 2018
Journal
Pages
430850
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