Nuclear expansion and pore opening are instant signs of neuronal hypoxia and can identify poorly fixed brains
Abstract
The initial phase of neuronal death is not well characterized. Here, we show that expansion of the nuclear membrane without losing its integrity along with peripheralization of chromatin are immediate signs of neuronal injury. Importantly, these changes can be identified with commonly used nuclear stains and used as markers of poor perfusion-fixation. Although frozen sections are widely used, no markers are available to ensure that the observed...
Paper Details
Title
Nuclear expansion and pore opening are instant signs of neuronal hypoxia and can identify poorly fixed brains
Published Date
Oct 3, 2018
Journal
Volume
8
Issue
1
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