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Par-Cteno-Genesis or Cteno Par-Genesis

Published on Sep 29, 2018in bioRxiv
· DOI :10.1101/431114
Miguel Salinas-Saavedra3
Estimated H-index: 3
(UF: University of Florida),
Mark Q. Martindale58
Estimated H-index: 58
(UF: University of Florida)
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Abstract
In bilaterians and cnidarians, embryonic and epithelial cell-polarity are regulated by the interactions between Par proteins, Wnt/PCP signaling pathway, and cell-cell adhesion. Par proteins are highly conserved across Metazoa, including ctenophores. But strikingly, ctenophore genomes lack components of the Wnt/PCP pathway and cell-cell adhesion complexes; raising the question if ctenophore cells are polarized by mechanisms involving Par proteins. Here, by using immunohistochemistry and live-cell imaging overexpression of specific mRNAs, we describe for the first time the subcellular localization of selected Par proteins in blastomeres and epithelial cells during the embryogenesis of the ctenophore Mnemiopsis leidyi . We show that these proteins distribute differently compared to what has been described for other animals. This differential localization might be related with the emergence of different junctional complexes during Metazoa evolution. Data obtained here challenge the ancestry of the apicobasal cell polarity and raise questions about the homology of epithelial tissue across the Metazoa.
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Published on Aug 30, 2018in Molecular Biology and Evolution 14.80
Leslie S. Babonis7
Estimated H-index: 7
(Whitney Laboratory for Marine Bioscience),
Melissa B. DeBiasse8
Estimated H-index: 8
(Whitney Laboratory for Marine Bioscience)
+ 5 AuthorsJoseph F. Ryan22
Estimated H-index: 22
(Whitney Laboratory for Marine Bioscience)
Published on Feb 1, 2018in Developmental Cell 9.19
Shizue Ohsawa8
Estimated H-index: 8
(Kyoto University),
John Vaughen3
Estimated H-index: 3
(Stanford University),
Tatsushi Igaki21
Estimated H-index: 21
(Kyoto University)
Epithelial tissues robustly respond to internal and external stressors via dynamic cellular rearrangements. Cell extrusion acts as a key regulator of epithelial homeostasis by removing apoptotic cells, orchestrating morphogenesis, and mediating competitive cellular battles during tumorigenesis. Here, we delineate the diverse functions of cell extrusion during development and disease. We emphasize the expanding role for apoptotic cell extrusion in exerting morphogenetic forces, as well as the str...
Published on Dec 1, 2017in Nature Communications 11.88
Meng Zhu3
Estimated H-index: 3
(University of Cambridge),
Chuen Yan Leung6
Estimated H-index: 6
(University of Cambridge)
+ 1 AuthorsMagdalena Zernicka-Goetz49
Estimated H-index: 49
(University of Cambridge)
Establishment of cell polarity in the mammalian embryo is fundamental for the first cell fate decision that sets aside progenitor cells for both the new organism and the placenta. Yet the sequence of events and molecular mechanism that trigger this process remain unknown. Here, we show that de novo polarisation of the mouse embryo occurs in two distinct phases at the 8-cell stage. In the first phase, an apical actomyosin network is formed. This is a pre-requisite for the second phase, in which t...
Published on Dec 1, 2017in Current Biology 9.19
Roberto Feuda9
Estimated H-index: 9
(California Institute of Technology),
Martin Dohrmann14
Estimated H-index: 14
(LMU: Ludwig Maximilian University of Munich)
+ 5 AuthorsDavide Pisani32
Estimated H-index: 32
(UoB: University of Bristol)
The relationships at the root of the animal tree have proven difficult to resolve, with the current debate focusing on whether sponges (phylum Porifera) or comb jellies (phylum Ctenophora) are the sister group of all other animals [1; 2; 3; 4 ; 5]. The choice of evolutionary models seems to be at the core of the problem because Porifera tends to emerge as the sister group of all other animals (“Porifera-sister”) when site-specific amino acid differences are modeled (e.g., [6 ; 7]), whereas Cteno...
Published on Nov 1, 2017in Nature Ecology and Evolution
Nathan V. Whelan10
Estimated H-index: 10
(AU: Auburn University),
Kevin M. Kocot18
Estimated H-index: 18
(UA: University of Alabama)
+ 5 AuthorsKenneth M. Halanych42
Estimated H-index: 42
(AU: Auburn University)
Ctenophora, comprising approximately 200 described species, is an important lineage for understanding metazoan evolution and is of great ecological and economic importance. Ctenophore diversity includes species with unique colloblasts used for prey capture, smooth and striated muscles, benthic and pelagic lifestyles, and locomotion with ciliated paddles or muscular propulsion. However, the ancestral states of traits are debated and relationships among many lineages are unresolved. Here, using 27...
Published on Oct 1, 2017in Development 5.76
Charles F. Lang1
Estimated H-index: 1
(U of C: University of Chicago),
Edwin Munro23
Estimated H-index: 23
(U of C: University of Chicago)
PAR proteins constitute a highly conserved network of scaffolding proteins, adaptors and enzymes that form and stabilize cortical asymmetries in response to diverse inputs. They function throughout development and across the metazoa to regulate cell polarity. In recent years, traditional approaches to identifying and characterizing molecular players and interactions in the PAR network have begun to merge with biophysical, theoretical and computational efforts to understand the network as a patte...
Published on Jun 15, 2017in Human Molecular Genetics 4.54
Fares Kharfallah2
Estimated H-index: 2
(UdeM: Université de Montréal),
Marie Claude Guyot3
Estimated H-index: 3
(UdeM: Université de Montréal)
+ 6 AuthorsZoha Kibar21
Estimated H-index: 21
(UdeM: Université de Montréal)
Published on Jun 1, 2017in Nature Reviews Molecular Cell Biology 43.35
Mitchell T. Butler4
Estimated H-index: 4
,
John B. Wallingford43
Estimated H-index: 43
Planar cell polarity — the asymmetric distribution of proteins in the plane of a cell sheet — dictates the orientation of various subcellular structures and drives collective cell rearrangements. Better understanding of this conserved axis of polarity can shed light on the mechanisms of morphogenetic processes and explain the underlying causes of human birth defects.
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