Abstract 16301: Oxidative Mitochondrial DNA Damage Affects Mitochondrial Respiration and Cardiac Development in Mice With Altered DNA Repair

Impaired mitochondrial proliferation and function may lead to heart failure. Mitochondrial biogenesis during postnatal cardiac development in rodents is accompanied by oxidative mitochondrial (mt) DNA damage and repair. How mtDNA damage is linked to mitochondrial biogenesis is unknown, but our previous data suggest that site-specific mtDNA oxidation is involved in regulation of mtDNA replication. Here we tested the hypothesis that modulation of...