Using superparamagnetic iron oxide nanoparticles to enhance bioavailability of quercetin in the intact rat brain

Quercetin (QT) as a bioactive flavonoid has a potential therapeutic activity for numerous neuronal injuries and neurodegenerative diseases. However, the low absorption rate of QT, especially through the blood-brain barrier, restricts its bioactivity in the body. The current research took the advantage of superparamagnetic iron oxide nanoparticles (SPIONs) to enhance the bioavailability of quercetin.Quercetin conjugated with SPIONs was prepared...