Application of quality by design for optimization of spray drying process used in drying of Risperidone nanosuspension

The objective of present study was to optimize spray drying of Risperidone (RIS) nanosuspension for achieving lower particle size, higher yield and good compressibility of spray dried powder using Quality by design approach. RIS nanosuspension was prepared by anti-solvent precipitation technique using poloxamer 68 and Poloxamer 127 as stabilizers. 3 level 2 factorial design was applied using two independent factor variables viz., X1: feed pump...