Pathway analysis of GWAS loci identifies novel drug targets and repurposing opportunities

Volume: 24, Issue: 6, Pages: 1232 - 1236
Published: Jun 1, 2019
Abstract
Genome-wide association studies (GWAS) have made considerable progress and there is emerging evidence that genetics-based targets can lead to 28% more launched drugs. We analyzed 1589 GWAS across 1456 pathways to translate these often imprecise genetic loci into therapeutic hypotheses for 182 diseases. These pathway-based genetic targets were validated by testing whether current drug targets were enriched in the pathway space for the same...
Paper Details
Title
Pathway analysis of GWAS loci identifies novel drug targets and repurposing opportunities
Published Date
Jun 1, 2019
Volume
24
Issue
6
Pages
1232 - 1236
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