Rewiring urea cycle metabolism in cancer to support anabolism
Abstract
Cancer cells reprogramme metabolism to maximize the use of nitrogen and carbon for the anabolic synthesis of macromolecules that are required during tumour proliferation and growth. To achieve this aim, one strategy is to reduce catabolism and nitrogen disposal. The urea cycle (UC) in the liver is the main metabolic pathway to convert excess nitrogen into disposable urea. Outside the liver, UC enzymes are differentially expressed, enabling the...
Paper Details
Title
Rewiring urea cycle metabolism in cancer to support anabolism
Published Date
Sep 7, 2018
Journal
Volume
18
Issue
10
Pages
634 - 645
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