Molecular profiling of tumour and ctDNA in a gastrointestinal cancer cohort at an academic cancer centre

Background: Circulating tumour DNA (ctDNA) can provide a minimally invasive liquid biopsy that may better capture tumour heterogeneity than archival biopsies. We report results of ctDNA and tumour molecular profiling from a gastrointestinal subset of patients recruited to the Tumour characterisation to Guide Experimental Targeted Therapy Trial (TARGET). Methods: 68 patients (pts) with metastatic small bowel cancer (SBC) or colorectal cancer...