When Should Guidelines Change? A Clarion Call for Evidence Regarding the Benefits and Risks of Screening for Colorectal Cancer at Earlier Ages

Colorectal cancer (CRC) is a significant public health problem and a major focus of research and clinical care for gastroenterologists; thus, changes in CRC practice guidelines confer a large impact on patients, clinicians, health care systems, and insurers. Despite substantial decreases in the incidence of CRC over the last 30 years, cancers of the colon and rectum are still the second leading cause of cancer death in many countries. In the...