Allosteric regulators selectively prevent Ca2+-feedback of CaV and NaV channels.

eLife7.70
Volume: 7
Published: Sep 10, 2018
Abstract
Calmodulin (CaM) serves as a pervasive regulatory subunit of CaV1, CaV2, and NaV1 channels, exploiting a functionally conserved carboxy-tail element to afford dynamic Ca2+-feedback of cellular excitability in neurons and cardiomyocytes. Yet this modularity counters functional adaptability, as global changes in ambient CaM indiscriminately alter its targets. Here, we demonstrate that two structurally unrelated proteins, SH3 and cysteine-rich...
Paper Details
Title
Allosteric regulators selectively prevent Ca2+-feedback of CaV and NaV channels.
Published Date
Sep 10, 2018
Journal
Volume
7
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