Copper mediated amyloid-β binding to Transthyretin

Transthyretin (TTR), a homotetrameric protein that transports thyroxine and retinol both in plasma and in cerebrospinal (CSF) fluid provides a natural protective response against Alzheimer’s disease (AD), modulates amyloid- β (A β ) deposition by direct interaction and co-localizes with A β in plaques. TTR levels are lower in the CSF of AD patients. Zn 2+ , Mn 2+ and Fe 2+ transform TTR into a protease able to cleave A β . To explain these...