Polygenic risk score for breast cancer in high-risk women.

1508 Background: While assessment of genetic contribution to breast cancer (BC) risk was once limited to high-penetrance genes such as BRCA1/2, additional genes conferring two- to five-fold increased risks of BC, as well common SNPs with relative risks ranging 1.03-1.57, have recently been identified. Although several reports suggest that a score based on combined genotypes across a large number of SNPs may have substantial predictive value for...