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Blood fatty acid status and clinical outcomes in dialysis patients: A systematic review

Published on Sep 21, 2018in Nutrients4.171
· DOI :10.3390/nu10101353
Ban Hock Khor1
Estimated H-index: 1
(UKM: National University of Malaysia),
Sreelakshmi Sankara Narayanan1
Estimated H-index: 1
(Taylors University)
+ 5 AuthorsTilakavati Karupaiah9
Estimated H-index: 9
Sources
Abstract
Blood fatty acids (FAs) are derived from endogenous and dietary routes. Metabolic abnormalities from kidney dysfunction, as well as cross-cultural dietary habits, may alter the FA profile of dialysis patients (DP), leading to detrimental clinical outcomes. Therefore, we aimed to (i) summarize FA status of DP from different countries, (ii) compare blood FA composition between healthy controls and DP, and (iii) evaluate FA profile and clinical endpoints in DP. Fifty-three articles from 1980 onwards, reporting FA profile in hemodialysis and peritoneal DP, were identified from PubMed, Embase, and the Cochrane library. Studies on pediatric, predialysis chronic kidney disease, acute kidney injury, and transplant patients were excluded. Moderate to high levels of n-3 polyunsaturated fatty acids (PUFA) were reported in Japan, Korea, Denmark, and Sweden. Compared to healthy adults, DP had lower proportions of n-3 and n-6 PUFA, but higher proportion of monounsaturated fatty acids. Two studies reported inverse associations between n-3 PUFAs and risks of sudden cardiac death, while one reported eicosapentaenoic acid + docosahexaenoic acid)/arachidonic acid ratio was inversely associated with cardiovascular events. The relationship between all-cause mortality and blood FA composition in DP remained inconclusive. The current evidence highlights a critical role for essential FA in nutritional management of DP.
  • References (90)
  • Citations (1)
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References90
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#1Ban Hock Khor (UKM: National University of Malaysia)H-Index: 1
#2Sreelakshmi Sankara Narayanan (UKM: National University of Malaysia)H-Index: 1
Last. Tilakavati KarupaiahH-Index: 9
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Low-grade chronic inflammation is prevalent in patients undergoing haemodialysis (HD) treatment and is linked to the development of premature atherosclerosis and mortality. The non-pharmacological approach to treat inflammation in HD patients through nutritional intervention is well cited. We aimed to assess the efficacy of different nutritional interventions at improving inflammatory outcomes in HD patients, based on markers such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumour nec...
8 CitationsSource
#2William S. Harris (USD: University of South Dakota)H-Index: 48
Purpose of Review Fatty acid (FA) profiles in different blood compartments are reflections of both diet and metabolism, and some FA levels are related to disease risk.
6 CitationsSource
#1Jyrki K. Virtanen (University of Eastern Finland)H-Index: 32
#2Jaakko Mursu (University of Eastern Finland)H-Index: 30
Last. Tomi-Pekka Tuomainen (University of Eastern Finland)H-Index: 24
view all 4 authors...
There are concerns that high intake of n-6 polyunsaturated fatty acids (PUFA) may promote inflammation, because the end-product of n-6 PUFA metabolism, arachidonic acid, is a precursor for pro-inflammatory eicosanoids. Our aim was to investigate cross-sectional associations of the serum n-6 PUFAs, objective biomarkers for exposure, with serum high-sensitivity C-reactive protein (CRP), a key inflammation marker. The study included 1287 generally healthy men aged 42–60 years from the population-ba...
7 CitationsSource
#1Lauren A. RoachH-Index: 1
#2Kelly LambertH-Index: 11
Last. Barbara J. MeyerH-Index: 28
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SUMMARYBackground People on haemodialysis (HD) are at risk of consuming a poor quality diet. This includes inadequate intake of omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA). Objective This study aims to investigate diet quality, with a particular focus on n-3 LCPUFA intake, in a population of incentre HD patients. Design Dietary intake was measured using three 24 hour recalls; the Polyunsaturated food frequency questionnaire (PUFA FFQ) and the Total Diet Score (TDS). Dietary intak...
3 CitationsSource
#1Magdalena Pazda (University of Gdańsk)H-Index: 1
#2Piotr Stepnowski A (University of Gdańsk)H-Index: 43
Last. Adriana Mika (University of Gdańsk)H-Index: 8
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Gas chromatography-mass spectrometry (GC-MS) is a preferred method for fatty acid (FA) analysis in biofluids from patients with metabolic diseases. Complex characteristics of FAs make their analysis particularly challenging. Selection of an appropriate chromatographic column is particularly important component of the process as it provides optimal separation and detection of possibly all FAs present in the sample. However, no accurate protocol for comparative evaluation of capillary columns for ...
2 CitationsSource
#1Hang Su (Jiangnan University)H-Index: 3
#2Ruijie Liu (Jiangnan University)H-Index: 11
Last. Xingguo Wang (Jiangnan University)H-Index: 27
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Purpose: The aim of the present study was to investigate the effect of increasing dietary linoleic acid (LA) intake on the blood concentrations of inflammatory markers including cytokines, acute phase reactants and adhesion molecules in adults. Methods: We comprehensively searched PubMed, Embase and Cochrane Library for eligible studies. Overall, 30 randomized controlled studies involving 1377 subjects were included for meta-analysis. Results: No significant effect of higher LA intake was observ...
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#1Andresa Marques de Mattos (USP: University of São Paulo)H-Index: 3
#2José Abrão Cardeal da Costa (USP: University of São Paulo)H-Index: 8
Last. Paula Garcia Chiarello (USP: University of São Paulo)H-Index: 14
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Objective The aim of the study was to explore the effects of n-3 polyunsaturated fatty acids (PUFA) supplementation in physiological doses on oxidative stress (OS) and dyslipidemia in patients on hemodialysis (HD). Design and Methods Randomized, double-blind, controlled, experimental trial. A total of 88 HD patients ≥18 years old and on HD for at least 6 months. A total of 43 patients received 1.28 g/day of n-3 PUFA, and 45 other patients received soybean oil for 12 weeks. Both oil supplements w...
10 CitationsSource
#1Dan-Qian Chen (MOE: Chinese Ministry of Education)H-Index: 20
#2Hua Chen (MOE: Chinese Ministry of Education)H-Index: 29
Last. Ying-Yong Zhao (MOE: Chinese Ministry of Education)H-Index: 42
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Author(s): Chen, Dan-Qian; Chen, Hua; Chen, Lin; Vaziri, Nosratola D; Wang, Ming; Li, Xiang-Ri; Zhao, Ying-Yong | Abstract: The kidney plays a central role in elimination of metabolic waste products and regulation of low-molecular weight metabolites via glomerular filtration, tubular secretion and reabsorption. Disruption of these processes results in profound changes in the biochemical milieu of the body fluids, which contribute to complications of chronic kidney disease (CKD) by inducing cytot...
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A progressive chronic kidney disease results in retention of various substances that more or less contribute to dysfunction of various metabolic systems. The accumulated substances are denominated ...
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#1Shinga Esaki (Memorial Hospital of South Bend)H-Index: 2
#2Motokazu-Tohru Iwahori (Memorial Hospital of South Bend)H-Index: 1
Last. Toshiyuki NakaoH-Index: 15
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Objective To evaluate the effects of a nutritional formula enriched with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in tube-fed bedridden hemodialysis patients. Design A prospective, multicenter, single-arm study. Setting Koyukai Memorial Hospital, Orimoto Hospital, and Chofu Hospital, Japan. Subjects Eleven tube-fed bedridden hemodialysis patients. Intervention Patients were fed a nutritional formula enriched with EPA and DHA for 12 weeks. Main Outcome Measures Body weight; body...
3 CitationsSource
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#1Benjamin Gollasch (Charité)H-Index: 1
#2Inci DoganH-Index: 1
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Omega-3 (n-3) fatty acids have beneficial cardiovascular effects, perhaps also in chronic kidney disease (CKD) patients. A low omega-3 index is an independent cardiovascular risk factor in end-stage renal disease (ESRD) dialysis patients. However, the plasma measurements invariably ignore circulating blood cells, including the preponderant erythrocytes (RBCs). We measured fatty acids (HPLC-MS lipidomics) in all components of the circulating blood, since RBC n-3 fatty acid status has been linked ...
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#1B.H. Khor (UKM: National University of Malaysia)H-Index: 2
#2Sharmela Sahathevan (UKM: National University of Malaysia)H-Index: 4
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