Evaluation of bilosomes as nanocarriers for transdermal delivery of tizanidine hydrochloride:in vitroandex vivooptimization
Abstract
Bilosomes were developed in order to investigate their efficacy as nanocarriers for transdermal delivery of Tizanidine HCl (TZN), a skeletal muscle relaxant with low oral bioavailability. Full factorial experimental design consisting of 27 combinations was generated to study the effects of surfactant type, surfactant-to-cholesterol ratio and the amount of bile salt on the entrapment efficiency (EE), the vesicle size (VS) and in vitro dissolution...
Paper Details
Title
Evaluation of bilosomes as nanocarriers for transdermal delivery of tizanidine hydrochloride:in vitroandex vivooptimization
Published Date
Nov 13, 2018
Journal
Volume
29
Issue
2
Pages
171 - 182
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