Rapid CLIP dissociation from MHC II promotes an unusual antigen presentation pathway in autoimmunity

Volume: 215, Issue: 10, Pages: 2617 - 2635
Published: Sep 5, 2018
Abstract
A number of autoimmunity-associated MHC class II proteins interact only weakly with the invariant chain–derived class II–associated invariant chain peptide (CLIP). CLIP dissociates rapidly from I-Ag7 even in the absence of DM, and this property is related to the type 1 diabetes–associated β57 polymorphism. We generated knock-in non-obese diabetic (NOD) mice with a single amino acid change in the CLIP segment of the invariant chain in order to...
Paper Details
Title
Rapid CLIP dissociation from MHC II promotes an unusual antigen presentation pathway in autoimmunity
Published Date
Sep 5, 2018
Volume
215
Issue
10
Pages
2617 - 2635
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