Conservation of epigenetic regulation by the MLL3/4 tumour suppressor in planarian pluripotent stem cells
Abstract
Currently, little is known about the evolution of epigenetic regulation in animal stem cells. Here we demonstrate, using the planarian stem cell system to investigate the role of the COMPASS family of MLL3/4 histone methyltransferases that their function as tumor suppressors in mammalian stem cells is conserved over a long evolutionary distance. To investigate the potential conservation of a genome-wide epigenetic regulatory program in animal...
Paper Details
Title
Conservation of epigenetic regulation by the MLL3/4 tumour suppressor in planarian pluripotent stem cells
Published Date
Sep 7, 2018
Journal
Volume
9
Issue
1
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