Reversal of albuminuria by combined AM6545 and perindopril therapy in experimental diabetic nephropathy

Background and Purpose The endocannabinoid (EC) system has been implicated in the pathogenesis of diabetic nephropathy (DN). We investigated the effects of peripheral blockade of the cannabinoid CB 1 receptor as an add‐on treatment to ACE‐inhibition in type 1 diabetic mice (DM) with established albuminuria. Experimental Approach Renal functional parameters (albumin excretion rate, creatinine clearance), tubular injury, renal structure, both EC...