Pre-eclampsia and maternal–fetal conflict

Published on Jan 1, 2018in Evolution, Medicine, and Public Health4.4
· DOI :10.1093/emph/eoy029
P. J. Varas Enriquez1
Estimated H-index: 1
(UvA: University of Amsterdam),
Luseadra McKerracher4
Estimated H-index: 4
(McMaster University),
Michael G. Elliot10
Estimated H-index: 10
(UG: University of Groningen)
  • References (6)
  • Citations (1)
In this speculative paper, I consider the relationship between oxidative stress and the evolution of placentation in eutherian mammals. I argue that epitheliochorial placentation, in which fetal tissues remain separated from maternal blood throughout gestation, has evolved as a protective mechanism against oxidative stress arising from pregnancy, particularly in species with unusually long gestation periods and unusually large placentas. Human beings comprise an unusual species that has the life...
11 CitationsSource
#2Gustaaf A. Dekker (University of Adelaide)H-Index: 56
Last. G. Chaout (French Institute of Health and Medical Research)H-Index: 50
view all 4 authors...
This workshop had four main objectives: (A) Trying to look at the preeclampsia (PE) problem “from the Space Shuttle”: why preeclampsia has emerged in humans (a specific human reproductive feature among 4300 mammal species)? (B) Epidemiology: there are major geographical differences concerning early onset PE and late onset PE throughout the world. (C) Vascular: The very promising use of pravastatin in the treatment of the vascular maternal syndrome (based on the metabolism of carbon monoxide (CO)...
14 CitationsSource
#1Christopher W. G. Redman Frcp Frcog (John Radcliffe Hospital)H-Index: 83
#2I.L. Sargent (John Radcliffe Hospital)H-Index: 60
Last. Anne Cathrine Staff (University of Oslo)H-Index: 40
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Abstract Incomplete spiral artery remodelling is the first of two stages of pre-eclampsia, typically of early onset. The second stage comprises dysregulated uteroplacental perfusion and placental oxidative stress. Oxidatively stressed syncytiotrophoblast (STB) over-secretes proteins that perturb maternal angiogenic balance and are considered to be pre-eclampsia biomarkers. We propose that, in addition and more fundamentally, these STB-derived proteins are biomarkers of a cellular (STB) stress re...
197 CitationsSource
#1Isabella Capellini (Durham University)H-Index: 15
#2Chris VendittiH-Index: 22
Last. Robert A. BartonH-Index: 39
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Abstract: The mammalian placenta exhibits striking interspecific morphological variation, yet the implications of such diversity for reproductive strategies and fetal development remain obscure. More invasive hemochorial placentas, in which fetal tissues directly contact the maternal blood supply, are believed to facilitate nutrient transfer, resulting in higher fetal growth rates, and to be a state of relative fetal advantage in the evolution of maternal‐offspring conflict. The extent of interd...
50 CitationsSource
#1Michael G. Elliot (SFU: Simon Fraser University)H-Index: 10
#2Bernard J. Crespi (SFU: Simon Fraser University)H-Index: 56
Brain growth is a key trait in the evolution of mammalian life history. Brain development should be mediated by placentation, which determines patterns of resource transfer from mothers to fetal offspring. Eutherian placentation varies in the extent to which a maternal barrier separates fetal tissues from maternal blood. We demonstrate here that more invasive forms of placentation are associated with substantially steeper brain‐body allometry, faster prenatal brain growth and slower prenatal bod...
29 CitationsSource
Pragnancy has commonly been viewed as a cooperative interaction between a mother and her fetus. The effects of natural selection on genes expressed in fetuses, however, may be opposed by the effects of natural selection on genes expressed in mothers. In this sense, a genetic conflict can be said to exist between maternal and fetal genes. Fetal genes will be selected to increase the transfer of nutrients to their fetus, and maternal genes will be selected to limit transfers in excess of some mate...
829 CitationsSource
Cited By1
#1Mirna Marinić (U of C: University of Chicago)H-Index: 1
#2Katelyn M. Mika (U of C: University of Chicago)H-Index: 5
Last. Vincent J. Lynch (UB: University at Buffalo)H-Index: 28
view all 4 authors...
The developmental origins and evolutionary histories of cell types, tissues and organ systems contribute to the ways in which their dysfunction leads to disease. In mammals for example, the nature and extent of maternal-fetal interactions, how those interactions develop, and their evolutionary history likely influence diseases of pregnancy such as infertility and preterm birth. Here we show genes that evolved to be expressed at the maternal-fetal interface in Eutherian (Placental) mammals play e...
#2Gustaaf A. Dekker (University of Adelaide)H-Index: 56
Last. Marco SciosciaH-Index: 19
view all 5 authors...
Abstract The 11th workshop on Immunology of preeclampsia in Reunion 2018 celebrated its 20th candle In this paper we try to summarize the main tracks of reflections during these two decades. First, of course, the advances in immunology of reproduction in the field of preeclampsia, which was poorly developed 2 decades ago when we first started in 1998. But, this workshop has not been dedicated only to immunology. Second, one of the main reflections has always been, workshop after workshop: “why d...
1 CitationsSource