Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells

Volume: 9, Issue: 1
Published: Sep 27, 2018
Abstract
Innate lymphoid cells (ILCs) play critical roles in mucosal barrier defense and tissue homeostasis. While ILCs are depleted in HIV-1 infection, this phenomenon is not a generalized feature of all viral infections. Here we show in untreated SIV-infected rhesus macaques (RMs) that ILC3s are lost rapidly in mesenteric lymph nodes (MLNs), yet preserved in SIV + RMs with pharmacologic or natural control of viremia. In healthy uninfected RMs,...
Paper Details
Title
Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells
Published Date
Sep 27, 2018
Volume
9
Issue
1
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