18F‐FPEB PET/CT Shows mGluR5 Upregulation in Parkinson's Disease

BACKGROUND AND PURPOSE Dopamine and glutamate reciprocally regulate each other in some of the neurocircuits affected by Parkinson's disease (PD). The objective of this pilot study was to explore relationships between these neurotransmitter systems with positron emission tomography. METHODS The sample consisted of nine patients with PD and eight healthy volunteers (HVs). Dynamic images of the brain were acquired after the IV administration of...