Direct Electrophysiological Evidence for Prefrontal Control of Hippocampal Processing during Voluntary Forgetting

•We investigated iEEG oscillations in DLPFC and hippocampus of epilepsy patients•Voluntary forgetting increases DLPFC 3–5 Hz power and hippocampal 6–18 Hz power•Three complementary directed connectivity metrics reveal DLPFC→HC coupling•Directional DLPFC→HC information flow is specific for to-be-forgotten items Forgetting does not necessarily reflect failure to encode information but can, to some extent, also be voluntarily controlled. Previous...