miR-125b promotes tau phosphorylation by targeting the neural cell adhesion molecule in neuropathological progression
Abstract
MicroRNAs, small noncoding RNAs, not only regulate gene expression at the post-transcriptional level in a variety of physiological processes but also accompany the initiation and progression of a vast number of diseases, including dementia. While miR-125b has been shown to be aberrantly expressed in some dementia patients, its role in the pathological process remains ambiguous. Presenilin-1/2 conditional double knockout mice exhibit a range of...
Paper Details
Title
miR-125b promotes tau phosphorylation by targeting the neural cell adhesion molecule in neuropathological progression
Published Date
Jan 1, 2019
Journal
Volume
73
Pages
41 - 49
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