NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development
Abstract
The activation of natural killer (NK) cells depends on a change in the balance of signals from inhibitory and activating receptors. The activation threshold values of NK cells are thought to be set by engagement of inhibitory receptors during development. Here, we found that the activating receptor NKG2D specifically set the activation threshold for the activating receptor NCR1 through a process that required the adaptor DAP12. As a result,...
Paper Details
Title
NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development
Published Date
Sep 17, 2018
Journal
Volume
19
Issue
10
Pages
1083 - 1092
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