Engineered CRISPR-Cas9 nuclease with expanded targeting space
Abstract
Expanding the targeting space of Cas9 CRISPR-Cas9 associates with a guide RNA to target and cleave a specific DNA site next to a protospacer adjacent motif (PAM). Streptococcus pyogenes Cas9 (SpCas9), the one most often used for genome editing, only recognizes the NGG sequence (where N is any nucleobase) as the PAM, which restricts regions in the genome that can be targeted. To address this limitation, Nishimasu et al. created a SpCas9 variant...
Paper Details
Title
Engineered CRISPR-Cas9 nuclease with expanded targeting space
Published Date
Sep 21, 2018
Journal
Volume
361
Issue
6408
Pages
1259 - 1262
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Notes
History