Stimuli-responsive nanoparticles by thermal treatment of bovine serum albumin inside its complexes with chondroitin sulfate
Abstract
We combine electrostatic polysaccharide/protein complexation with subsequent thermal denaturation of proteins to produce chondroitin sulfate/bovine serum albumin nanoparticles that do not lose their integrity at neutral and basic pH. Light scattering at a wide angular range shows that nanoparticle size (radius of gyration and hydrodynamic radius) and molar mass may be tuned by the CS/BSA mass ratio while the irreversible protein-protein contacts...
Paper Details
Title
Stimuli-responsive nanoparticles by thermal treatment of bovine serum albumin inside its complexes with chondroitin sulfate
Published Date
Feb 1, 2019
Journal
Volume
87
Pages
602 - 610
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