Progranulin in the hematopoietic compartment protects mice from atherosclerosis

Progranulin is a circulating protein that modulates inflammation and is found in atherosclerotic lesions. Here we determined whether inflammatory cell-derived progranulin impacts atherosclerosis development.Ldlr-/- mice were transplanted with bone marrow from wild-type (WT) or Grn-/- (progranulin KO) mice (referred to as Tx-WT and Tx-KO, respectively).After 10 weeks of high-fat diet feeding, both groups displayed similarly elevated plasma levels...