Metabolic reprogramming of acute lymphoblastic leukemia cells in response to glucocorticoid treatment
Abstract
Glucocorticoids (GCs) are metabolic hormones with immunosuppressive effects that have proven effective drugs against childhood acute lymphoblastic leukemia (ALL). Yet, the role of metabolic reprogramming in GC-induced ALL cell death is poorly understood. GCs efficiently block glucose uptake and metabolism in ALL cells, but this does not fully explain the observed induction of autophagy and cell death. Here, we have performed parallel time-course...
Paper Details
Title
Metabolic reprogramming of acute lymphoblastic leukemia cells in response to glucocorticoid treatment
Published Date
Aug 28, 2018
Journal
Volume
9
Issue
9
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