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Nitrite-stimulated Gastric Formation of S-nitrosothiols As An Antihypertensive Therapeutic Strategy

Published on Jan 25, 2019in Current Drug Targets2.642
· DOI :10.2174/1389450119666180816120816
Gustavo H. Oliveira-Paula10
Estimated H-index: 10
(USP: University of São Paulo),
Jose E. Tanus-Santos46
Estimated H-index: 46
(USP: University of São Paulo)
Abstract
  • References (200)
  • Citations (3)
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References200
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#1Justine Bonetti (University of Lorraine)H-Index: 2
#2Yi Zhou (University of Lorraine)H-Index: 1
Last. Caroline Gaucher (University of Lorraine)H-Index: 10
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Abstract S-Nitrosothiols, a class of NO donors, demonstrate potential benefits for cardiovascular diseases. Drugs for such chronic diseases require long term administration preferentially through the oral route. However, the absorption of S-nitrosothiols by the intestine, which is the first limiting barrier for their vascular bioavailability, is rarely evaluated. Using an in vitro model of intestinal barrier, based on human cells, the present work aimed at elucidating the mechanisms of intestina...
2 CitationsSource
#1Danielle A. Guimaraes (USP: University of São Paulo)H-Index: 14
#2Madla A. Passos (USP: University of São Paulo)H-Index: 7
Last. Jose E. Tanus-Santos (USP: University of São Paulo)H-Index: 46
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Abstract Cardiac hypertrophy is a common consequence of chronic hypertension and leads to heart failure and premature death. The anion nitrite is now considered as a bioactive molecule able to exert beneficial cardiovascular effects. Previous results showed that nitrite attenuates hypertension-induced increases in reactive oxygen species (ROS) production in the vasculature. Whether antioxidant effects induced by nitrite block critical signaling pathways involved in cardiac hypertrophy induced by...
9 CitationsSource
#1Gustavo H. Oliveira-Paula (USP: University of São Paulo)H-Index: 10
#2Riccardo Lacchini (USP: University of São Paulo)H-Index: 16
Last. Jose E. Tanus-Santos (USP: University of São Paulo)H-Index: 46
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Abstract Propofol anesthesia is usually accompanied by hypotension, which is at least in part related to enhanced endothelial nitric oxide synthase (NOS3)-derived NO bioavailability. We examined here whether NOS3 polymorphisms (rs2070744, 4b/4a VNTR, rs3918226 and rs1799983) and haplotypes affect the changes in blood pressure and NO bioavailability induced by propofol. Venous blood samples were collected from 168 patients at baseline and after 10 min of anesthesia with propofol 2 mg/kg administe...
2 CitationsSource
#1Lucas C. Pinheiro (USP: University of São Paulo)H-Index: 12
#2Graziele C. Ferreira (USP: University of São Paulo)H-Index: 8
Last. Jose E. Tanus-Santos (USP: University of São Paulo)H-Index: 46
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Abstract Nitrite reduces blood pressure (BP) in both clinical and experimental hypertension. This effect is attributable to the formation of nitric oxide (NO) and other NO-related species, which may be improved by ascorbate or other antioxidants. However, the BP responses to oral nitrite result, at least in part, of increased gastric S-nitrosothiol formation. This study tested the hypothesis that ascorbate may destroy S-nitrosothiols and therefore not all doses of ascorbate enhance the BP respon...
4 CitationsSource
#1Letícia S. Ferraz (UFABC: Universidade Federal do ABC)H-Index: 3
#2Carolina M. Watashi (UFABC: Universidade Federal do ABC)H-Index: 3
Last. Tiago Rodrigues (UFABC: Universidade Federal do ABC)H-Index: 17
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Melanoma is a malignant proliferative disease originated from melanocyte transformations, which are characterized by a high metastatic rate and mortality. Advances in Nanotechnology have provided useful new approaches and tools for antitumor chemotherapy. The aim of this study was to investigate the molecular mechanisms underlying chitosan nanoparticles containing S-nitrosomercaptosuccinic acid (S-nitroso-MSA-CS) induced cytotoxicity in melanoma cells. S-Nitroso-MSA-CS induced concentration-depe...
4 CitationsSource
#1Gustavo H. Oliveira-Paula (USP: University of São Paulo)H-Index: 10
#2Lucas C. Pinheiro (USP: University of São Paulo)H-Index: 12
Last. Jose E. Tanus-Santos (USP: University of São Paulo)H-Index: 46
view all 7 authors...
Abstract Propofol anesthesia is usually accompanied by hypotension. Studies have shown that the hypotensive effects of propofol increase in patients treated with angiotensin-converting enzyme inhibitors (ACEi). Given that both propofol and ACEi affect nitric oxide (NO) signaling, the present study tested the hypothesis that ACEi treatment induces pronounced hypotensive responses to propofol by increasing NO bioavailability. In this study we evaluated 65 patients, divided into three groups: hyper...
2 CitationsSource
#2Ilya R. Bederman (Case Western Reserve University)H-Index: 15
Last. Nadzeya Marozkina (Case Western Reserve University)H-Index: 3
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AbstractContext: Exogenous nitrogen oxides must be made bioavailable to sustain normal physiology because nitric oxide synthase (NOS) deficient mice are viable. In the stomach, S-nitrosoglutathione (GSNO) is formed from ingested nitrite and high levels of airway glutathione (GSH) that are cleared and swallowed. However, gastric GSNO may be broken down by nutrients like ascorbic acid (AA) before it is absorbed.Objective: To study the effect of AA on GSNO formation and stability.Materials and meth...
3 CitationsSource
#1Tristan Pascart (university of lille)H-Index: 8
#2Pascal Richette (French Institute of Health and Medical Research)H-Index: 40
ABSTRACTIntroduction: Gout is a common disease responsible for recurrent flares triggered by the deposition of monosodium urate crystals secondary to longstanding hyperuricaemia. The management of gout implies both the treatment of flares and the treatment of hyperuricaemia itself. Recent improvement in the understanding of the disease led to the development of new drugs.Areas covered: This review covers data related to ‘old’ treatments of flares and hyperuricaemia, evidence on the recently appr...
14 CitationsSource
#1Célio Damacena-Angelis (State University of Campinas)H-Index: 1
#2Gustavo H. Oliveira-Paula (USP: University of São Paulo)H-Index: 10
Last. Jose E. Tanus-Santos (USP: University of São Paulo)H-Index: 46
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Abstract Nitrite and nitrate restore deficient endogenous nitric oxide (NO) production as they are converted back to NO, and therefore complement the classic enzymatic NO synthesis. Circulating nitrate and nitrite must cross membrane barriers to produce their effects and increased nitrate concentrations may attenuate the nitrite influx into cells, decreasing NO generation from nitrite. Moreover, xanthine oxidoreductase (XOR) mediates NO formation from nitrite and nitrate. However, no study has e...
10 CitationsSource
#1Jun Kobayashi (Josai University)H-Index: 23
Abstract Diet is associated with the development of cancer in the gastrointestinal (GI) tract, because dietary nitrate and nitrite are the main nitrosating agents that are responsible for the formation of carcinogenic N -nitroso compounds (NOCs) when nitrosatable substrates, such as amine and amide, are present in the GI tract. However, whether the nitroso compounds become beneficial S -nitroso compounds or carcinogenic NOCs might depend on dietary and environmental factors including food stuffs...
10 CitationsSource
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#1Stefan Ückert (MHH: Hannover Medical School)H-Index: 30
#2George T. Kedia (MHH: Hannover Medical School)H-Index: 8
Last. Markus A. Kuczyk (MHH: Hannover Medical School)H-Index: 43
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Objectives The benign prostatic syndrome, comprising lower urinary tract symptomatology secondary to benign prostatic hyperplasia/enlargement, represents a major health care issue in westernized countries. The pharmacological management involves alpha-adrenoceptor antagonists, intervention into the hormonal control of prostate growth using inhibitors of the enzyme 5-alpha-reductase, and stimulation of the nitric oxide/cyclic GMP pathway by tadalafil, an inhibitor of the phosphodiesterase type 5.
Source
#1Tiago Dal-Cin de Paula (USP: University of São Paulo)H-Index: 2
#2Graziele C. Ferreira (USP: University of São Paulo)H-Index: 8
Last. Jose E. Tanus-Santos (USP: University of São Paulo)H-Index: 46
view all 3 authors...
Source
#1Gustavo H. Oliveira-Paula (USP: University of São Paulo)H-Index: 10
#2Lucas C. Pinheiro (USP: University of São Paulo)H-Index: 12
Last. Jose E. Tanus-Santos (USP: University of São Paulo)H-Index: 46
view all 3 authors...
Abstract Hypertension is a multifactorial disease associated with impaired nitric oxide (NO) production and bioavailability. In this respect, restoring NO activity by using nitrite and nitrate has been considered a potential therapeutic strategy to treat hypertension. This possibility is justified by the understanding that both nitrite and nitrate may be recycled back to NO and also promote the generation of other bioactive species. This process involves a complex biological circuit known as the...
4 CitationsSource