Original paper
Mapping 3D genome organization relative to nuclear compartments using TSA-Seq as a cytological ruler
Abstract
While nuclear compartmentalization is an essential feature of three-dimensional genome organization, no genomic method exists for measuring chromosome distances to defined nuclear structures. In this study, we describe TSA-Seq, a new mapping method capable of providing a "cytological ruler" for estimating mean chromosomal distances from nuclear speckles genome-wide and for predicting several Mbp chromosome trajectories between nuclear...
Paper Details
Title
Mapping 3D genome organization relative to nuclear compartments using TSA-Seq as a cytological ruler
Published Date
Aug 28, 2018
Journal
Volume
217
Issue
11
Pages
4025 - 4048
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Notes
History