Metabolic and Transcriptional Modules Independently Diversify Plasma Cell Lifespan and Function
Abstract
Plasma cell survival and the consequent duration of immunity vary widely with infection or vaccination. Using fluorescent glucose analog uptake, we defined multiple developmentally independent mouse plasma cell populations with varying lifespans. Long-lived plasma cells imported more fluorescent glucose analog, expressed higher surface levels of the amino acid transporter CD98, and had more autophagosome mass than did short-lived cells. Low...
Paper Details
Title
Metabolic and Transcriptional Modules Independently Diversify Plasma Cell Lifespan and Function
Published Date
Aug 1, 2018
Journal
Volume
24
Issue
9
Pages
2479 - 2492.e6
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