Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations.
Abstract
Inherited mitochondrial DNA (mtDNA) mutations cause mitochondrial disease, but mtDNA mutations also occur somatically and accumulate during ageing. Studies have shown that the mutation load of some inherited mtDNA mutations decreases over time in blood, suggesting selection against the mutation. However, it is unknown whether such selection occurs in other mitotic tissues, and where it occurs within the tissue. Gastrointestinal epithelium is a...
Paper Details
Title
Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations.
Published Date
Dec 1, 2018
Journal
Volume
246
Issue
4
Pages
427 - 432
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Notes
History