Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study

To identify the genetic determinants of fracture risk and assess the role of 15 clinical risk factors on osteoporotic fracture risk.Meta-analysis of genome wide association studies (GWAS) and a two-sample mendelian randomisation approach.25 cohorts from Europe, United States, east Asia, and Australia with genome wide genotyping and fracture data.A discovery set of 37 857 fracture cases and 227 116 controls; with replication in up to 147 200...