Direct contact with intra-tissue senescent erythrocytes accumulated following endothelial injury triggers the acquisition of an osteoblastic phenotype by aortic valve interstitial cells

Aim: Intra-leaflet hemorrhage has been associated with faster progression of valve calcification in degenerative aortic stenosis (AS). However, past studies were performed during advanced stages of the disease on severely calcified valves, and do not establish a causal relationship between hemorrhage and calcium deposition. In the present study, we assessed the spatio-temporal relationship between intra-leaflet hemorrhage and calcium deposition...