Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels
Abstract
Background & Aims null Several steps in the HBV life cycle remain obscure because of a lack of robust in vitro infection models. These steps include particle entry, formation and maintenance of covalently closed circular (ccc) DNA, kinetics of gene expression and viral transmission routes. This study aimed to investigate infection kinetics and cccDNA dynamics during long-term culture. null Methods null We selected a highly permissive...
Paper Details
Title
Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels
Published Date
Dec 1, 2018
Journal
Volume
69
Issue
6
Pages
1231 - 1241
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History