Elevated expression of p53 in early colon polyps in a pig model of human familial adenomatous polyposis
Abstract
Familial adenomatous polyposis (FAP) is a hereditary predisposition to formation of colon polyps that can progress to colorectal cancer (CRC). The severity of polyposis varies substantially within families bearing the same germline mutation in the adenomatous polyposis coli (APC) tumour suppressor gene. The progressive step-wise accumulation of genetic events in tumour suppressor genes and oncogenes leads to oncogenic transformation, with driver...
Paper Details
Title
Elevated expression of p53 in early colon polyps in a pig model of human familial adenomatous polyposis
Published Date
Aug 25, 2018
Journal
Volume
59
Issue
4
Pages
485 - 491
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