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Antioxidant and anti-inflammation of enzymatic-hydrolysis residue polysaccharides by Lentinula edodes

Published on Dec 1, 2018in International Journal of Biological Macromolecules4.78
· DOI :10.1016/j.ijbiomac.2018.08.114
Zhenzhen Ren7
Estimated H-index: 7
(SDAU: Shandong Agricultural University),
Wenbo Liu1
Estimated H-index: 1
(SDAU: Shandong Agricultural University)
+ 5 AuthorsLe Jia18
Estimated H-index: 18
(SDAU: Shandong Agricultural University)
Abstract
Abstract The present work investigated the antioxidative, anti-inflammatory and organ protective effects of residue polysaccharide (RPS) and its enzymatic-RPS (ERPS) of Lentinula edodes against the LPS-induced sepsis in mice. The results demonstrated that ERPS showed superior effects on inhibiting serum activities of CKMB, LDH, AST, ALP and ALT, lowing the serum levels of BUN, CRE and UA, as well as improving the antioxidant status (SOD, CAT, GSH-P X and T-AOC) than RPS. Moreover, the levels of TNF-α (667.17 ± 36.72 pg/mL), IL-6 (288.47 ± 16.48 pg/mL), and IL-1β (61.62 ± 3.54 pg/mL) on ERPS-treated mice (600 mg/kg bw) significantly lower than that in the LPS-induced mice. Furthermore, the histological observations also indicated the significant recovery effect on organs. The RPS yield was 5.03%, and the ERPS yield was 73.65%. Moreover, the physical properties of polysaccharides were investigated by HPGPC, FT-IR, NMR, GC–MS and AFM analysis, and the results indicated that ERPS was a homogeneous heteropolysaccharide by (1 → 6)- and (1 → 3)-linkages. These conclusions suggested that ERPS might be suitable for functional foods and potentially effective candidate medicine for the treatment of sepsis and its complications.
  • References (42)
  • Citations (1)
References42
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#2Kiran Thakur (Hefei University of Technology)H-Index: 9
Last.Zhao-Jun Wei (Hefei University of Technology)H-Index: 14
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#1Tao Feng (Shanghai Institute of Technology)H-Index: 9
#2Ke Wang (Shanghai Institute of Technology)H-Index: 2
Last.Zhimin Xu (Louisiana State University Agricultural Center)H-Index: 22
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#1Meng Meng (Tianjin University of Science and Technology)H-Index: 8
#2Dai Cheng (Tianjin University of Science and Technology)H-Index: 7
Last.Chunling Wang (Tianjin University of Science and Technology)H-Index: 16
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#1Huajie Zhao (SDAU: Shandong Agricultural University)H-Index: 9
#2Shangshang Li (SDAU: Shandong Agricultural University)H-Index: 8
Last.Yu LiuH-Index: 2
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Cited By1
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#1Ximeng Lin (NWAFU: Northwest A&F University)
#2Xiaolong Ji (NWAFU: Northwest A&F University)H-Index: 5
Last.Qiang Peng (NWAFU: Northwest A&F University)H-Index: 11
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#1Ying Cai (SYSU: Sun Yat-sen University)H-Index: 1
#2Wen Liu (SYSU: Sun Yat-sen University)H-Index: 1
Last.Qiongfeng Liao (Guangzhou University of Chinese Medicine)H-Index: 10
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