Mulberry leaf extract displays antidiabetic activity in db/db mice via Akt and AMP-activated protein kinase phosphorylation

Background: Augmenting glucose utilization in skeletal muscle via the phosphatidylinositol-3 kinase (PI3kinase)/protein kinase B (Akt) pathway or the adenosine monophosphate (AMP)-activated protein kinase(AMPK) pathway is necessary to regulate hyperglycemia in patients with type 2 diabetes mellitus. Objective: We investigated the effect of mulberry leaf extract (MLE) on glucose uptake in skeletal muscle cellsand explored its in vivo antidiabetic...