The comings and goings of PARP-1 in response to DNA damage

Volume: 71, Pages: 177 - 182
Published: Aug 23, 2018
Abstract
Poly(ADP-ribose) polymerase (PARP) enzymes are broadly involved in the cellular response to DNA damage. PARP-1 is the chief human PARP enzyme involved in the DNA damage response, acting as a first responder that detects DNA strand breaks, and contributes to repair pathway choice and the efficiency of repair through modulation of chromatin structure and through interaction with and modification of a multitude of DNA repair factors. This...
Paper Details
Title
The comings and goings of PARP-1 in response to DNA damage
Published Date
Aug 23, 2018
Journal
Volume
71
Pages
177 - 182
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